Interleukin 12 p40 subunit (IL-12p40; Uniprot# Q8CJE6) is a component of the bioactive cytokines IL-12 and IL-23. Existing in either a monomeric or homodimeric form it is induced in excess of the other subunits of IL-12 and IL-23. Most known for providing negative feedback by competing for the IL-12 receptor it also functions as a chemoattractant for macrophages and is associated with several pathogenic inflammatory responses.
|Source||HEK293, Met1-Ser327, with C-terminal His Tag|
|Purity||>95% by SDS-PAGE|
|Formulation||Lyophilized from 1X PBS with Trehalose|
|Preparation and Storage|
|Reconstitution||Reconstitute at 25μg/mL in sterile PBS containing at least 0.1% protein|
|Storage||5 years at -80°C; 2 years at -20°C or 4°C|
Upon reconstitution: 5 years at -80°C; 2 years at -20°C