Interleukin 4 (IL-4; UniProt #Q60440 ) is a cytokine that that functions as a potent regulator of immunity. It is secreted primarily by mast cells, Th2 cells, eosinophils, and basophils. IL-4 signals through the IL-4R α-chain which activates several pathways. This activation can lead to B cell proliferation, survival of T and B cells and chemokine production. IL-4 has been shown to have a role in allergic asthma through its regulation of TH2 cell proliferation and IgE synthesis, and atopy or excessive IgE production has been associated with elevated levels of IL-4 in response to allergens.
| Description | |
| Source | HEK293, Met1-Phe147, with C-terminal His Tag |
| Purity | >95% by SDS-PAGE |
| Predicted Molecular Mass | 18.5 kDa |
| SDS-PAGE | 22.4-31.8 kDa |
| Applications | ELISA, WB |
| Formulation | Lyophilized from 1X PBS with Trehalose |
| Preparation and Storage | |
| Reconstitution | Reconstitute at 25μg/mL in sterile PBS containing at least 0.1% protein |
| Shipping | Ambient |
| Storage | 5 years at -80°C; 2 years at -20°C or 4°C Upon reconstitution: 5 years at -80°C; 2 years at -20°C |
