Interleukin 4 (IL-4) is a cytokine that that functions as a potent regulator of immunity. It is secreted primarily by mast cells, Th2 cells, eosinophils, and basophils. IL-4 signals through the IL-4R α-chain which activates several pathways. This activation can lead to B cell proliferation, survival of T and B cells and chemokine production. IL-4 has been shown to have a role in allergic asthma through its regulation of TH2 cell proliferation and IgE synthesis, and atopy or excessive IgE production has been associated with elevated levels of IL-4 in response to allergens.
| Description | |
|---|---|
| Immunogen | HEK293-derived recombinant Golden Hamster IL-4. Asn20-Phe147. |
| Reactivity | Hamster |
| Source | Mouse monoclonal IgG1 |
| Purification | Protein G purified from hybridoma cell culture supernatant |
| Applications | ELISA (Detection) |
| Formulation | Lyophilized from PBS with Trelahose Reconstitute in 100μL ddH20 to 1 mg/mL |
| Shipping | Ambient |
| Storage | 5 years at -20°C to -80°C as supplied 1 month at 4°C after reconstitution with preservative 1 year at -20°C to -80°C after reconstitution |
| Expiration | See lot specific CoA |
 | Hamster IL-4 Luminex Assay Capture: Hamster IL-4 clone HM4-1C6 (Cat # M2035) |
