Interleukin 6 (IL-6) is a soluble cytokine that can effect inflammation, immune response, and hematopoiesis. IL-6 signals through IL-6R, which can occur as a transmembrane or a soluble receptor that is found in serum. IL-6 is generated immediately following environmental stresses such as infections and tissue injuries. Dysregulation of IL-6, which can lead to over production, may contribute to chronic inflammation and autoimmunity.
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